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doi: 10.1046/J.1523-1755.2001.59780037.X 85 NohH.KingG

The CD38/NAD/SIRTUIN1/EZH2 Axis mitigates cytotoxic CD8 T cell function and identifies patients with SLE prone to infections

However, due to the potential invoke of polycythemia, pulmonary artery hypertension and possibly occurrence of cancer, pre-clinical and clinical research aiming to guide the proper dosage and frequency of the pharmacological administration under these pathological conditions that need long term treatment are urgently awaited