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[22] Flumazenil (given as a continuous low-dose infusion) shows promise in refractory cases but requires close cardiac monitoring

A loss of the unaltered tert -butyl chain can yield m/z 396.0177 (C 15 H 15 BrN 3 O 5 + , 3.3 ppm), ruling out this alkyl chain as the site of hydroxylation

The hyaluronic acid shell targets CD44, enabling sNP@G/IR to home actively to the tumor site, where hyaluronidase in the extracellular matrix degrades the hyaluronic acid shell

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