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By activating A sensory nerve fibers in the penile and lumbosacral skin, TENS can inhibit the transmission of sensory signals to the spinal cord and cerebral cortex, thereby reducing glans sensitivity (55)

Hypoxia Inducible Factor 1 (HIF-1), a crucial transcriptional regulator of hypoxic responses, is upregulated under oxidative stress, which subsequently triggers a hypoxic response, enhances the transcription of angiogenic factors, such as vascular endothelial growth factor (VEGF), and mediates autophagy, mitophagy, and aerobic glycolysis [134]

This causes the muscle pain that anyone who has visited the gym will understand, delayed onset muscle soreness, or DOMS

The other four trials, like ours, are single arm trials

1 Introduction The glutathione peroxidase family (GPX) is a family of antioxidant enzymes that are an essential class of selenoenzymes in mammals (Zhao et al., 2019)