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Pharmacology of Curcuma longa

These compounds serve as signaling molecules to adapt the plant response to environmental constraints, but may also enhance oxidative stress damages

Yeste A, Mascanfroni ID, Nadeau M, Burns EJ, Tukpah AM, Santiago A et al

Safety Profile Across all six human trials and the extensive preclinical work, the safety picture is quite clean: No serious adverse events attributed to the compound No effect on IGF-1 No impairment of glucose tolerance or insulin sensitivity No genotoxic activity Most common side effects: mild injection site irritation, occasional headache or fatigue all transient This is genuinely one of the better-characterized peptides from a safety standpoint, largely because it actually went through a formal development process with proper clinical oversight

Previous studies have identified disulfiram, traditionally used for alcohol aversion therapy, as an agent that downregulates FDX1 expression (263,264)