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These differential metabolic responses shed light on the unique mechanisms through which various -lactam classes exert their antibacterial effects and can provide insights for future therapeutic strategies aimed at overcoming antibiotic resistance (Lee et al., 2018)

We will enroll 300 AIS patients at up to 50 sites with baseline NIHSS 4, who can receive study drug within 4.5-24 hours of last known well (LKW), and with evidence of core-penumbra mismatch but not receiving standard of care acute stroke reperfusion therapies, will be eligible