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Muscle toxicity, including a severe form called rhabdomyolysis, may rarely occur with colchicine, particularly when it is administered with other drugs known to have this effect

Paulose et al

J Dairy Sci 97(12):73867393 Gonzalez A et al (2020) Role of oxidative stress in hepatic and extrahepatic dysfunctions during nonalcoholic fatty liver disease (NAFLD)

The data is striking: in a Phase 2 trial published in the New England Journal of Medicine, the highest doses produced an average ~24% body-weight reduction at 11 months more than any currently approved weight-loss drug (American Diabetes Association)