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10.1016/j.clnu.2016.09.008 170 WakabayashiH.AraiH.InuiA

First, TMAO has been demonstrated to stimulate inflammation and oxidative stress, both of which are significant factors in the progression of CKD (Lau et al., 2018)

Mitochondrial overload and incomplete oatty acid oxidation contribute to skeletal muscle insulin resistance

Time-course studies in myotube cultures of neonatal rat hindlimbs showed that androgens, but not E2 or progesterone, increased calcium transience and inositol triphosphate (IP3) production in under 1-min, with dose-dependent increases of extracellular signal-regulated kinase 1/2 (ERK1/2) protein phosphorylation within 5-min through Ras and MEK activity [119]