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In a rat I/R model, Rb2 administration reduced infarct size, improved mitochondrial ultrastructure, and decreased serum levels of cardiac injury markers (lactate dehydrogenase [LDH] and creatine kinase [CK])

The complexity of the zonal cerebellar circuitry as well as its wide-spread connectivity in motor and non-motor behavior necessitate an equal level of sophistication in examining the responses to cerebellar stimulation

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Typically, patients with a deficiency might start with more frequent injections, often weekly, and then switch to monthly maintenance doses once levels stabilize