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Izumi, T

3c, d, Supplementary Data 2)

Unregulated use calls for clearer guidelines and more research

Marom, R., Lee, Y

MetS has since been identified as a significant risk factor for CVDs, substantially increasing the likelihood of heart disease, stroke, and type 2 diabetes ( In 2004, the National Heart, Lung, and Blood Institute provided the first definition of Cardio-Renal Syndrome (CRS) as the result of interactions between the kidneys and other circulatory compartments that increase circulating volume, exacerbating symptoms of HF and disease progression. ( Building upon the foundation of MetS, in 2023, the American Heart Association (AHA) introduced the cardiovascular-kidney-metabolic (CKM) Syndrome, which was defined as: A systemic disorder characterized by pathophysiological interactions among metabolic risk factors, CKD, and the cardiovascular system, leading to multiorgan dysfunction and high rates of adverse cardiovascular outcomes