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For example, in the STEP 1 trial , patients taking semaglutide lost an average of 14.9% of their body weight over 68 weeks , compared with just 2.4% in the placebo group (NEJM study)

(PubMed) Mazokopakis EE, Starakis IK

This has been particularly well-studied using large cohort studies including cohorts enrolled in the Nurses Health Study (NHS) and Black Womens Health Study (BWHS)

after FDA inspection of the companys facility found products to be adulterated because they were prepared, packed, or held under conditions that do not meet Current Good Manufacturing Practices (CGMP)