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Moreover, stem cell-derived exosomes are known to have anti-inflammatory, immunomodulatory, and antifibrotic capabilities, which have the potential to be used in the treatment of numerous inflammatory and chronic respiratory disorders [156, 157] Modulation strategies to overcome the barriers in the tumor microenvironment To a large extent, drug delivery using NPs is impeded by tumor heterogeneity, including atypical vasculature, stiff ECM, excessively generated glutathione (GSH), hypoxia, acidic pH, immune suppression, and their association with the TME [13, 158]

Whether this translates to humans remains unproven

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2459-C LEVERAGING NAFLDSYM TO IDENTIFY OPTIMAL COMBINATION THERAPIES FOR NASH PATIENTS Maria E Trujillo 1 , Saswata Talukdar 2 , Grant Generaux 3 , Michael Kelley 3 , Shailendra Tallapaka 1 , Ramin Mehrani 1 and Scott Q

(2011) Glutathione syn- thesis is essential for pollen germination in vitro.BMC Plant Biology 11, 54