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doi: 10.1016/j.ijpharm.2023.123738 62

4.2 Reduced glucotoxicity and lipotoxicity Glucotoxicity is characterized by irreversible tissue and cell damage resulting from insulin resistance and persistently elevated glucose levels stemming from excessive carbohydrate intake (Mota et al., 2016)

10 However, after two cases of progressive multifocal leukoencephalopathy (PML) were confirmed in TYSABRI-treated patients, the drug was voluntarily removed from the market in February 2005, pending complete safety review

Endometrioid ovarian carcinoma On ultrasound both ovaries are markedly enlarged and contain cystic components with intracystic solid components (arrows)