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REDEFINE 1 (2025

Tirzepatide also significantly reduced the sleep apnoea-specific hypoxic burden, a measure that comprises the frequency, duration and depth of oxygen desaturation associated with sleep events, and is considered a better predictor of cardiovascular risk and mortality in sleep apnoea

Published studies have documented measurable increases in BDNF expression in animal models following Semax administration, with some research reporting elevations exceeding 50% relative to baseline in specific brain regions