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Imaging and spectroscopy studies provide indirect evidence of altered sodium and extracellular water handling, with signals distinct from both obesity and lymphedema

confirmed via microelectrode detection that the average pH of human degenerate NP is 6.5 0.3, significantly lower than the pH of healthy IVD (7.1 0.2)

The slight decreases observed in the IM2 curve at selected time points (e.g., 20, 40, 90 and 140 min) arise from experimental variability, including sampling and analytical measurement

We also summarize the potential mechanisms by which ROS regulates immune checkpoint expression, immune cells activity, and differentiation