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The high neutrophil to lymphocyte ratio in critically ill patients, the intense neutrophil infiltration in pulmonary capillaries and into pulmonary alveoli, and the increased levels of circulating neutrophil extracellular traps (NETs) clearly show neutrophil involvement/activation favoring intense ROS production and oxidative damage caused by lipid peroxidation, and protein and DNA oxidation (Komaravelli and Casola, 2014

Binding affinities ( K D ) were calculated by nonlinear regression assuming a one-site binding model in GraphPad Prism v10.6.1 (GraphPad Software Inc., Boston, USA)

10.2220/biomedres.40.125 81

Che L, Chi W, Qiao Y, Zhang J, Song X, Liu Y, et al

Water kefir grains consist of a vast spectrum of microbial communities including 70% Lactobacillus spp., 10% Leuconostoc spp., 10% Acetobacter spp., 5% Bifidobacterium spp., and 5% other microorganisms (Fiorda et al., 2017)