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10.1016/j.molcel.2017.09.009 22 ChenJ.MarksE.LaiB.ZhangZ.DuceJ

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CPEO displays notable genetic heterogeneity, being sporadic in around 50% of cases involving single large de novo mtDNA deletion [182], with inherited forms involving mutations in genes such as RRM2B, TWNK, OPA1, POLG , and ANT1 [183]

Additionally, metformin inhibits mitochondrial respiratory chain complex I, which lowers proton leak and ROS generation in hepatocyte mitochondria, thereby reducing hepatocyte apoptosis to treat DILI (99)

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