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167 Triptolide, a diterpenoid compound discussed for its anti-inflammatory potential, also exhibited secondary antioxidant effects

doi: 10.1182/blood.V92.4.1191 41

You do have to look at systemic inflammation, you do have to look at leaky gut

Lu J-F et al (2007) The role of peroxisomal ABC transporters in the mouse adrenal gland: the loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage