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The ETC has a ubiquinone-cytochrome region (complex III) which also generates O 2 from O 2

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Nat Biotechnol 25:11651170 Deng S, Zhang W, Zhang B, Hong R, Chen Q, Dong J, Chen Y, Chen Z, Wu Y (2015) Radiolabeled cyclic arginine-glycine-aspartic (RGD)-conjugated iron oxide nanoparticles as single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI) dual-modality agents for imaging of breast cancer

The controlled senescence of fibroblasts, when occurring in a controlled environment, facilitates the growth of precancerous epithelium and gives rise to tumor cells