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Subjects received an 80 mg/kg dose of one APAP formulation, followed by a washout period and subsequent administration of the second 80 mg/kg formulation of APAP

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82 Noncanonical pathway In lung homogenates from Fra-2 transgenic mice, upregulation of TGF- leads to increased JUN-B expression and binding of the AP-1 complex to the meprin promoter, resulting in elevated meprin expression