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Infiltration of MPs has been found in even the most secluded ecosystems, such as a remote high-altitude lake in the Tibetan Plateau in China, with MPs reaching as high as 5.56 items L 1 in surface water ( The pervasive environmental presence of MPs and NPs has escalated concerns for human health, with the brain being a potentially vulnerable target

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doi: 10.1007/s10753-021-01464-5 333 RoblesJPZamoraMAdan-CastroESiqueiros-MarquezLde la EscaleraGMClappC

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Here, by a systematic review of the available data, we will critically assess the physiopathological relevance of glutamate receptors in the regulation of cancer and immune cells in the TME and provide some unifying hypotheses for futures research on the role of glutamate receptors in the immune modulation of the tumor