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Although lactylation sites have been identified across various tissues, comprehension of tissue-specific regulatory mechanisms remains limited

OttoCKaemmererUIllertBMuehlingBPfetzerNWittigRet al

44 In the event of glucose deprivation, the overexpression of GRP94 in BCBM cells leads to upregulation of the anti-apoptotic proteins B-cell lymphoma 2 (BCL2) and inhibitor of apoptosis proteins (IAPs) and engagement of autophagy to promote cancer cell survival

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REDD1 activates the TSC1/TSC2 complex, leading to downregulation of mammalian target of rapamycin complex 1 (mTORC1) activity 25