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2 The native hormone has a serious pharmaceutical liability: it is prone to aggregation into amyloid fibrils and has a plasma half-life measured in minutes, which is why the first amylin-based drug, pramlintide, had to be injected before every major meal

Images were collected using the 365 nm (DAPI) and 488 nm (Alexa-488) channels on a Zeiss LSM confocal microscope by sequential line scanning

Because it acts on the brain, the most common side effect is nausea (affecting roughly 40% of users)

Supplementary information Supplementary Figures 1 - 26, Supplementary Tables 1 - 27, Supplementary Methods 1 - 2 and Supplementary References (PDF 11856 kb) Rights and permissions This work is licensed under a Creative Commons Attribution 4.0 International License

Its long-term effects, clinical relevance, and therapeutic potential remain open questions requiring significantly more data