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Another genetic aberration is the mutation in the receptor tyrosine kinase FGFR3, which when overexpressed regulates MM lipid metabolism

J Acquir Immune Defic Syndr , 2004

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Regulatory T cells, myeloid-derived suppressor cells and tumor-associated macrophages skewed toward an M2-like phenotype accumulate, while immunosuppressive mediators are upregulated, keeping local immune reactivity at a low level [14, 16]