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Theriogenology 143:139147 Molinari F, Frattini M (2013) Functions and regulation of the PTEN gene in colorectal cancer

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-glutamyl kinase (GK) encoded by PRO1 in eukaryotes or proB in prokaryotes, the first enzyme in proline biosynthetic pathway, catalyzes the formation of intermediate -glutamyl phosphate, which if accumulated could partially react with cysteine to generate -GC, and then Gsh2 adds glycine to -GC to form GSH