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Fixed cells were incubated with primary antibodies overnight at 4 C

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Patients receiving combination therapy had a higher incidence of side effects compared to those on monotherapy (ratio 1.85:1)

PMID: 33821640 Eur J Med ChemDiscovery of (E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistant mutants