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Virulence 10, 910924

Medicinal chemistry and structure-activity relationships De novo syntheses of small molecule (Series 1 and Series 2) compounds were followed by an orthogonal screen that incorporated two distinct BLVRB substrates (FMN and DCPIP) 23 , followed by 8-point IC 50 curves for compounds displaying at least 50% BLVRB inhibitory activity at 1.5 ), which are solvent-exposed residues located in the loop regions

Furthermore, studies that have shown neurometabolite differences have not shown consistent results, likely because of differences in time of assessment post-injury, regions studied, heterogeneity of concussion presentation, or comparison groups