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Because pyridostigmine is a highly ionized quaternary ammonium compound, under normal conditions it does not readily cross the blood-brain barrier (BBB) (Dunn et al, 1997

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Microtubules may also be important for transporting vesicles to the apical and basal ends of elongating fiber cells, although neither function has been demonstrated in vivo

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Glyoxalases, the key enzymes in the detoxification of methylglyoxal, a byproduct of glycolysis and precursor of advanced glycation end-products, are compromised by oxidation and downregulation