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In a healthy circulatory system, blood freely flows through veins to the heart

10.1016/j.crbiot.2019.07.001 [DOI] [Google Scholar] Hemmat M

doi:10.1136/bmj.316.7140.1295

ROS can further activate epithelial cells and macrophages facilitating neutrophil, monocyte, and lymphocyte recruitment, and the recruited activated inflammatory cells subsequently enhance additional ROS generation, increasing the pro-oxidant burden (8085)