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Menendez JA, Vellon L, Mehmi I, et al

The integration of these molecular mechanisms, orchestrated by AMPK, underscores metformins comprehensive therapeutic benefits beyond glycemic control, encompassing anti-inflammatory, antioxidant, and cytoprotective effects (Figure 1)

7 Limitations and Potential Risks Despite promising results, certain limitations and risks must be considered: Limited Sample Sizes and Durations: Many clinical studies on AOD 9604 have relatively small sample sizes and short durations, which may affect the generalizability of their findings

Their schedules of administration are described for each experiment

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