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(2.1, 2.2) Initiate folic acid 400 mcg to 1000 mcg orally, once daily, beginning 7 days prior to the first dose of pemetrexed for injection and continue until 21 days after the last dose of pemetrexed for injection

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1 These PI3Ks typically include the PI3K and PI3K isoforms, which are composed of regulatory subunits containing SH2 domains and catalytic subunits