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doi: 10.1016/j.neulet.2006.11.031 159 OrdonezL

SnapShot: endogenous RNAi machinery and mechanisms

The trade-off is the side-effect profile (water retention, appetite, glucose drift) documented in trials

for example, in salt-sensitive hypertension, capsaicin modulates the AMPK/Akt/Nrf2 pathway to coordinately reduce oxidative stress and inflammatory cytokine expression, conferring organ protection (33, 106)