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Lab testing cannot diagnose oxidative stress as the cause of heart disease, and no single antioxidant marker can determine whether a person will experience a heart attack or stroke

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IV administration also introduces risks that oral supplementation does not: Contamination or excessive endotoxin exposure Sterility and compounding failures Infusion reactions Venous irritation or infection Dosing errors Additional cost and clinical complexity The FDA has reported adverse events among patients who received injectable compounded glutathione made with an unsuitable dietary ingredient

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This is due to low absorption in the intestine, and breakdown by enzyme activity