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Mitochondrial Respiratory Chain Dysfunction in Muscle From Patients With Amyotrophic Lateral Sclerosis

In xenografts, luteolin (100 mg/kg IV) reduced tumor burden and prolonged survival without systemic toxicity, supporting its potential as a safe adjunct targeting tumor stemness ( In Ca Ski cervical cancer cells, luteolin (25100 M) inhibited proliferation and induced intrinsic apoptosis characterized by caspase activation and mitochondrial dysfunction ( Transcriptomic analyses indicate that luteolin targets genes involved in IL-17 signaling, oxidative stress regulation, and homologous recombination repair (Zhao et al., 2023)

Therefore, metabolic reprogramming is used to optimize cellular function and enhance anti-tumor efficacy

Furthermore, Aldehyde dehydrogenase 1A3 (ALDH1A3) was observed to promote the tetramerization of PKM2, which facilitates lactate-induced lactylation of X-ray cross-complementing protein 1 (XRCC1) at the K247 site, directly leading to a diminished response of tumor cells to TMZ and radiation therapy

(A) Nude mice injected subcutaneously with NC and SLC3A2 knockout LN229 cells on day 35