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It is one of the most common causes of dementia worldwide, affecting millions of individuals and posing significant public health challenges (Lee et al

For example, inhibitors targeting histone demethylases (such as KDM5 inhibitors like CPI-455 or ryuvidine) have demonstrated efficacy in preclinical models by preventing the reversible repression of chromatin states necessary for DTP survival ( 4.2 Exploiting metabolic vulnerabilities of DTP cells Metabolic reprogramming observed in DTP cells provides another therapeutic opportunity

Immunofluorescence labeling of HSD3B in rat testes and Leydig cells Paraformaldehyde (PFA, 4%)-fixed testis sections or isolated Leydig cells (LCs) were subjected to immunofluorescence staining of 3-hydroxysteroid dehydrogenase (HSD3B)

doi: 10.3390/cancers11070931

Studies have reported that the use of bisphosphonates can delay bone metastasis in patients with breast cancer and improve overall survival (36,37)