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The area located at the C-terminus is hydrophilic due to the +2 protons, responsible for the lytic activity, for a total of +6 charges at physiological Ph (Shi et al., 2016)

They may have to re-visit their research plan, which could lead to extensive loss of time and effort

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While the potential benefits of dihexa in Alzheimers disease treatment is promising, it is important to note that further research is needed to fully understand its efficacy and safety in humans