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Clinics may also adjust protocols depending on whether sermorelin is being used for recovery, fat loss, or anti-aging

Clinical data insights: In a large placebo-controlled trial, tesamorelin raised IGF-1 by 181% on average, but about 5% of participants discontinued due to adverse events, most commonly musculoskeletal pain and injection-site irritation (Falutz et al., NEJM )

It may offer dual benefits to bodybuilders: increasing fat loss and recovery time

Example receptors shown for each receptor group

For a broader view of which peptides have achieved regulatory approval, see our pillar article: FDA Approved Peptides List 2026