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A linkage between leucine catabolism and isoprenoid metabolism has been studied and established in the fungus Aspergillus nidulans , providing precedence for this alternative pathway (Rodrguez et al

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7D-7E, the combination of DON and BSO abrogated synthesis of m+5 GSH, m+5 glutamate, m+5 -KG, m+4 succinate, m+4 malate, m+4 aspartate, m+4 dihydroorotate, m+3 UTP and m+3 CTP

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