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TAMs exert their antitumor effects through three main mechanisms: i) Secretion of inhibitory cytokines, which inhibit CD8+ T lymphocytes from destroying tumor cells, such as TGF- and IL-10 (181)

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The length of the interventions has varied from three to twelve months, as have the requirements for patient inclusion (e.g., baseline TSH cut-offs, antibody thresholds, and pregnancy status)