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AMAP also undergoes extensive CYP-mediated bioactivation to chemically reactive species in vitro and in vivo (Rashed and Nelson 1989

2020;115: e190405

While the experimental models employed in PD have shown connections to human health, it remains a daunting task to translate mechanisms of action observed in in vitro and in vivo studies of natural compounds to clinical outcomes in human trials, where it is a critical step in drug development

For remaining experiments adult animals at an age of 1012 weeks were used

Metabolomic analysis 4T1 cells were seeded in cell culture flasks (2 10 6 cells/flask) and incubated for 24 h