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GH also stimulates, through the JAK-STAT signaling pathway, [39] the production of insulin-like growth factor 1 (IGF-1, formerly known as somatomedin C), a hormone homologous to proinsulin

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Wang et al., 2022a) to effectively treat gastrointestinal disorders, like functional dyspepsia, IBS, and chronic constipation, as well as metabolic diseases such as obesity, insulin resistance, and T2DM

Gastrointestinal side effects, though common, are generally manageable (AbuHilal et al

Acetaldehyde Disrupts Tight Junctions and Adherens Junctions in Human Colonic Mucosa: Protection by EGF and L-Glutamine. American Journal of Physiology - Gastrointestinal and Liver Physiology 289 (2): G367G375