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Data are from the final Multiple Cause of Death Files, 2018-2022, and from provisional data for years 2023-2024, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program

In rodent secretagogue studies, the combined blend is typically administered at 100-300 mcg per dosing window (giving 50-150 mcg of each peptide), with 1-3 administrations per 24h cycle

The two higher energy bands of BNSCQDs correspond to * and n * transitions of the aromatic sp 2 domains and nonbonding orbitals, respectively, while the transition band at 440 nm is associated with the trapping of excited state energy by certain surface states

Patient and public involvement (PPI) was undertaken during study preparation to assess the clarity and acceptability of participant-facing materials