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We are aware that some of the subjects may have had genetically low concentrations of transcobalamin I (TCI), which is now known to be a benign condition that most probably does not need medical treatment [17]

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The potential for dangerous interactions, hormonal disruption, and additive side effects is entirely unknown, and no regulatory body endorses such combinations

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In fact, the best documented treatments such as lithium augmentation, switching to an MAOI, and electroconvulsive therapy are among the least utilized.60 Some evidence suggests that patients with atypical depression or treatment-resistant depression seem to respond well to MAOI therapy