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Key proteins such as P62 and Beclin-1 regulate autophagy and have emerged as important markers for disease progression, with P62 involved in both autophagy and inflammasome modulation 9

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Cardoso S, Moreira PI (2020) Antidiabetic drugs for Alzheimers and Parkinsons diseases: repurposing insulin, metformin, and thiazolidinediones

HDM house dust mite HIF1a hypoxiainducible factor 1 alpha: master transcriptional regulator of the cellular and systemic homeostatic response to hypoxia by activating under hypoxic conditions the transcription of genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, to increase oxygen delivery or facilitate metabolic adaptation to hypoxia

Antioxidant Effects and Mechanism of Silymarin in Oxidative Stress Induced Cardiovascular Diseases