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2DF, dose-dependent treatment with SP reduced the proportions of M1-like macrophages as well as increased the proportions of anti-inflammatory M2-like macrophages (mannose receptor CD206 as the phenotypic marker of M2-like macrophages), suggesting that SP inhibited the polarization of proinflammatory M1-like macrophages and promoted the differentiation of anti-inflammatory M2-like macrophages

The method of any one of embodiments 40-58, wherein the cannabinoid is CBD and THC, the cofactor or precursor thereof is niacinamide, the antioxidant is L-ergothioneine, and the mitophagy stimulant is present and is urolithin A

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Vitamin B-12 Injectable Solution 1000mcg/mL is a prescription cyanocobalamin injection used in dogs, cats, horses, cattle, sheep, and swine as a supplemental source of Vitamin B12. It is indicated for B12 deficiency linked to poor dietary intake, intestinal malabsorption, cobalt deficiency in ruminants, and gastrointestinal diseases that impair absorption

Li Q, Zhou HB, Liu JQ, Bai WF, Wang J, Yang ZJ, et al