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Oxidative imbalance, which results in oxidative stress, is associated with the development of numerous diseases, including cardiovascular diseases, e.g., myocardial ischemia, varicose vein, thrombosis, stroke (ischemia-reperfusion damage), but also diabetes, neurodegenerative diseases, can- cer, and many others [ 4 7 ]

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GPx4 is a selenocysteine-containing glutathione peroxidase whose core biochemical property is to utilize glutathione to specifically reduce phospholipid hydroperoxides in cell membranes

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