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Apoptosis operates through two distinct pathways: the intrinsic pathway, which is dependent on internal signaling, primarily regulated by the BCL-2 family of proteins and involves mitochondria interactions, and the extrinsic pathway, which is dependent of external signaling and independent of BCL-2 and mitochondrial involvement (Jan and Chaudhry, 2019)

After being returned to their racks mice were checked for signs of pain and distress and their weight monitored daily

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Notably, the induction of ferroptosis, either directly or indirectly, holds promise as a combinatorial strategy to enhance anti-PD-1/PD-L1 immunotherapy (Sun LL