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A short pharmacological interruption of the RA signaling in adult mice leads to a decrease in airway function, an increase in airway smooth muscles (ASM) thickness, and collagen disposition, resulting in ASM hypertrophy and airway remodeling [228,229]

LGD-4033 A randomized controlled trial found LGD-4033 to be well-tolerated in 76 healthy men after receiving dosages of 0.1, 0.3, or 1 mg per day for 21 days