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10.1080/14786419.2017.1385015 18 BahmanA

Wang M , Goy A, Martin P, Ramchandren R, Alexeeva J, Popat R, Avivi I, Advani R, Le Gouill S, Horowitz N, Yuan Z, Kranenburg B, Rizo A, Zhuang SH, Deraedt W, Rule S

United States and Western Europe : $30,000-$50,000 per treatment (bone marrow transplant costs reach up to $300,000)

doi: 10.5812/nms.10661 64 MathewsDMPeartJMSimRGJohnsonNPOSullivanSDerraikJGBet al

Cystine deprivation resulted in a time-dependent reduction of mTORC1 signaling, as evidenced by the gradual decrease in the phosphorylation of p70S6K (T389) and S6 (S235/236), which are downstream effectors of mTORC1 (Fig