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Because it lacks GH receptor agonism and does not elevate IGF-1 meaningfully, concerns about carpal tunnel, fluid retention, and glucose dysregulation that accompany full hGH therapy are less applicable

Conservative therapies, including physical modalities, pharmacotherapy, and behavioral interventions, offer symptomatic relief but do not halt the progression of degeneration (Xin et al., 2022)

doi: 10.4103/0974-7753.114700

Vitamin B5 additionally contributes to normal mental performance (EFSA)

Similarly to other plants, pomegranate leaves also contain high levels of flavone glycosides (e.g., luteolin and apigenin) (366)