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doi: 10.1208/s12248-017-0148-7 16 KimMSLeeSHSongMYYooTHLeeBKKimYS

John's wort for symptom-specific climacteric treatment--results of a large-scale, controlled, observational study

10.1358/dnp.2009.22.3.1325032 50 HallbergM

Prasad A, Andrews NP, Padder FA, Husain M, Quyyumi AA

The medication is primarily eliminated through protein catabolism rather than traditional hepatic metabolism, meaning liver disease typically does not substantially affect elimination rates